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In addition, mitochondrial dysfunction in stromal cells is the key causal factor triggering fibrosis-induced ovarian decline, and metformins reversal of ovarian fibrosis converges on related mitochondrial metabolic pathways that are upstream of oxidative stress and inflammation (Umehara et al., 2022)
doi: 10.1038/nature13198
Cognitive impairment may occur at the full range of ages for different reasons at different stages of life
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Qin J, Li Y, Cai Z, et al
