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It binds to the hydrophobic pocket of Bcl-2 family members and has shown efficacy against lung cancer, especially when combined with chemotherapy and radiation therapy

Most patients notice changes after just a few sessions

doi: 10.1146/annurev-med-050823-094312

When sustained, this pro-inflammatory CS milieu can compromise canonical RTK outputs and, in the case of InsRec, facilitate the emergence of IR [182,183,184]
