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While this mechanism is theoretically plausible, the role of HO-1 in different cell types and microenvironments remains controversial, as experimental findings are sometimes inconsistent ( In conclusion, HO-1 holds significant potential as a therapeutic target for atherosclerosis, but its clinical application faces many challenges

[DOI] [PMC free article] [PubMed] [Google Scholar] 79.Amores-Snchez M.a.I., Medina M.

doi: 10.1158/2326-6066.CIR-16-0193 104 NewtonRPriyadharshiniBTurkaLA

It was reported that compounds with structures containing COH and C=O functional groups can chelate metal ions

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