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But if the body has genetic mutations then these conversions dont happen well at all and the effect is the body does not get the absorption or use of the nutrient

113 A controlled trial that included 38 women with menopausal symptoms given 100 mg Pycnogenol daily and 33 similar women given no treatment for eight weeks found those given Pycnogenol had reduced symptom scores for a subset of six common symptoms: hot flashes, night sweats, mood swings, sleep difficulty, low libido, vaginal dryness, and irregular menstrual periods

Essen Bioscience)

Budiman ME, Bubenik JL, Miniard AC et al (2009) Eukaryotic initiation factor 4a3 is a selenium-regulated RNA-binding protein that selectively inhibits selenocysteine incorporation