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In addition, caffeine enhances the effects of convulsant compounds

The variable response can be explained by the intersubject variability in the proportion of phenytoin clearance attributed to CYP2C19 metabolism and whether the patient is a homozygous or heterozygous carrier of the mutant allele responsible for the CYP2C9 and/or CYP2C19 poor metabolizer phenotype

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Geriatr Gerontol Int 10(Suppl 1):S99S106 Al-Majed AA, Sayed-Ahmed MM, Al-Omar FA, Al-Yahya AA, Aleisa AM, Al-Shabanah OA (2006) Carnitine esters prevent oxidative stress damage and energy depletion following transient forebrain ischaemia in the rat hippocampus

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