nrf-2 keap 1 glutathione synthesis The NRF2, Thioredoxin, and System in Tumorigenesis and Anticancer Therapies Therapeutic targeting of the NRF2
Description
As mentioned above, GSH is synthesized only in the cytoplasmic matrix, but it is also found in intracellular organelles, including the mitochondria, nucleus, and endoplasmic reticulum
During this period nicotinamide N-methyltransferase (NNMT) was identified as a key enzyme involved in cellular methylation pathways and metabolic regulation
doi: 10.1186/1471-2407-8-60
10.1002/jsfa.9303 14 BarapatreA.MeenaA
De Minicis& Brenner, 2008
