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the dual function of Topoisomerases i.e., catalysis and religation, requires unimpeded reactivities of the cysteinyl residues that bind and affect the inter-subunit interactions of topoisomerase to achieve "global" effects
Furthermore, Vitamin C is a known tyrosinase inhibitor itself, meaning it provides a secondary layer of support for an even skin tone

10.1016/j.redox.2022.102365 42 GalluzziL.VitaleI.AaronsonS

Critically, this neuronal energy crisis is markedly exacerbated by a parallel collapse of glial metabolic support

Malnourished older people can have deficits of most micronutrients, including zinc, selenium, vitamin C, vitamin E, riboflavin, electrolytes, and others
