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They need to be present consistently to maintain the gene expression changes that drive collagen synthesis

Overall, VD rebalanced the cytokine milieu toward an anti-inflammatory state, highlighting its therapeutic potential in NASH

doi: 10.1016/j.bbi.2024.03.001 61 DengJLinXQinJLiQZhangYZhangQet al

A scoring system was used to grade the degree of lung injury in lung tissue analysis (Gojkovic et al., 2021a

1 Introduction 1.1 Historical background Since its discovery, the process of RNA interference (RNAi), as a method of gene silencing, has attracted keen interest for applications in medicine ( 1.2 Core mechanisms and pathways: the siRNA pathway as an antiviral defense mechanism In contrast to mammals, but similarly to plants, insects possess a separate machinery for processing of long dsRNAs into small RNAs ( 1.3 Early uses and concepts of RNAi in pest control Because of the feature of intracellular defense against viral infection, the process of RNAi is considered to be very efficient in all insects once the delivery in the cytoplasm occurs ( 1.4 Integration of the RNAi mechanism in a broader view of the regulation of innate immunity In model organisms such as Drosophila and mosquitoes, recent research has revealed the importance of dsRNA as a trigger of innate immunity pathways, beyond the RNAi mechanism