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Metformin and other natural products known to activate AMPK are currently being tested in clinical trials to determine their efficacy in treating various cancers (reviewed in [121])
and vi) no severe mental or cognitive disorders
[DOI] [PMC free article] [PubMed] [Google Scholar] 108.Denais CM, Gilbert RM, Isermann P, McGregor AL, te Lindert M, Weigelin B, et al
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Patients with severe phenotypes can present in infancy with hypoglycemia and lactic acidosis
