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HDL in metabolic syndrome have been reported to have decreased capacity to prevent oxidation of LDL and inhibit endothelial cell apoptosis (877,878)

These insights contribute to understanding of the complex interactions between ALDH2 and IRI, offering a foundation for development of targeted therapeutic interventions aimed at reducing tissue damage and improving clinical outcomes

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The epithelial cells of the renal tubule have a high concentration of GSH, no doubt because the kidneys function in toxin and waste elimination, and the epithelium of the renal tubule is exposed to a variety of toxic compounds