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Fatty acids accumulated in the vicinity of the mitochondria are susceptible to ROS-induced lipid peroxidation, which poses a lipotoxic threat to the mitochondrial DNA (mtDNA), RNA, and proteins, further compromising function ( Lipid dysregulation also disrupts the dynamic balance of mitochondria

doi: 10.1038/s41467-020-17818-w 9 WangYGWangTShiMZhaiB

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