glutathione d-lactic acidosis Understanding acidosis, a rare cause of metabolic PDF] D-Lactic Acidosis: More Prevalent

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10.1016/j.bbrc.2014.01.195 157 WangL.-x.ZhangS.-x.WuH.-j.RongX.-l.GuoJ

Tumor cells acquire Cys indirectly via peripheral glutamine using System X c as a carrier, SLC7A11 is upregulated in one-third of TNBC cells in vivo , and limiting glutamine uptake or inhibiting System X c activity increases intracellular ROS levels and slows TNBC metabolism (Timmerman et al., 2013)

The redox status and activity of BiP will be of particular interest, given its roles in protein folding, ERAD, protein translocation, and UPR signaling (Pobre et al., 2019), and the fact that oxidative modifications can alter the nature of its associations with nascent proteins (Wang et al., 2014) and with the translocation channel (Ponsero et al., 2017)

Tetramethylpyrazine ameliorates systemic streptozotocin-induced Alzheimer-like pathology