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Evaluation against tyrosinase activity revealed that one of the compounds ((S)-(5-(benzyloxy)-1-octyl-4-oxo-1,4- dihydropyridin-2-yl)methyl 2-amino-3-phenylpropanoate, ( 33b ) showed IC 50 values 12.6 and 4.0 M for monophenolase and diphenolase activities, respectively

Immunopharmacol 31, 140148

Stability and delivery method are key

Kluck R, Muller S, Jagodzinski C, Hohenfellner K, Buscher A, Kemper MJ, Oh J, Billing H, Thumfart J, Weber LT, Acham-Roschitz B, Arbeiter K, Tonshoff B, Hagenberg M, Kanzelmeyer N, Pavicic L, Haffner D, Zivicnjak M (2022) Body growth, upper arm fat area, and clinical parameters in children with nephropathic cystinosis compared with other pediatric chronic kidney disease entities

They were also asked if they were taking supplements that contained Vitamin-B and were excluded unless they agreed to stop taking them for the duration of their participation in the study