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In vitro , both CCK-8 assay and colony-formation assay showed that RRM2 overexpression significantly increased the proliferation rate and clone formation ability of TPC-1 cells, while knockdown of RRM2 significantly inhibited cell growth
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Apart from these functions, glutathione has also been linked to skin health and pigmentation control, leading to its popularity as a skin lightening agent
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These studies are particularly noteworthy given that ferroptosis has recently emerged as an attractive therapeutic target for certain cancers [115]
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Thanks to Pharmacodia database for retrieving clinical trial data
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Timing of approval can range from days to several weeks, affecting treatment initiation
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