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Description
In addition, it is now apparent that AD is multifactorial rather than a single disease (43)

ANTICUERPOS MONOCLONALES CONTRA DIANAS ESPECFICAS DEL CNCER: RITUXIMAB (MABTHERA) Con la aprobacin de rituximab en 1997 se inici la terapia con anticuerpos monoclonales dirigidos contra dianas especficas involucradas en la fisiopatologa del cncer

These outcomes align with the local effect theory
Persistent symptoms warrant reassessment rather than automatic dose escalation

The only downside is larger injection volumes
