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Most adverse effects reported in studies arise from supplementation doses far exceeding the dietary levels, highlighting the need for evidence-based guidelines to delineate thresholds for therapeutic versus harmful use

Hong H, Xu Y, Xu J, Zhang J, Xi Y, Pi H et al (2021) Cadmium exposure impairs pancreatic -cell function and exaggerates diabetes by disrupting lipid metabolism

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The authors noted an IAHG score of 11 indicating probable AIH and a Roussel Uclaf Causality Assessment Method (RUCAM) score of 5, indicating possible drug-induced liver injury (DILI)

10.1016/j.metabol.2008.10.009 Metabolism 304 SchermaM.DessiC.MuntoniA