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Impairments in GSH-associated pathways suggest reduced cellular defence and are therefore considered as markers of increased oxidative stress [15, 17]

This has been considered the arginine paradox. Several mechanisms have been proposed to explain this phenomenon
Alternatively, the mitochondrial-free cytosolic fractions were extracted in 800 L of the defined extraction solution, incubated on ice for 5 min, and cleared by centrifugation at 17,000 g for 10 min
