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Based upon available current medical literature and informations published on the ABBVIE website on PRODUODOPA following are the critical studies and outcomes which have been utilized for getting approval for regular utilization in patients

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People with low B12 may experience: Persistent fatigue or low energy Weakness Brain fog, concentration issues, or memory changes Low mood or irritability Pins and needles, numbness, or nerve-type sensations Mouth ulcers or a sore tongue Paleness or shortness of breath (if anaemia is present) Some symptoms can become more serious if deficiency is prolonged, particularly neurological symptoms

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Br J Dermatol 170:7886 Ruan L, Wang B, ZhuGe Q, Jin K (2015) Coupling of neurogenesis and angiogenesis after ischemic stroke