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Agents that can inhibit or reverse this metabolic switch can be pivotal in the advancement of cancer therapeutics with reduced side effects and improved efficacy
We summarize key mechanisms of action, categorize clinically relevant peptide classes, and address current limitations, including gaps in human data, safety considerations, and regulatory ambiguity
CRH-R1 mediates the action of CRH at corticotrophs by binding to CRH
doi: 10.1371/journal.pone.0122893 51 ZhaoYZhangT-RLiQFengLLiuYJiangW-Det al
