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Normally, mTOR is activated in the background of high levels of nutrients and energy substrates [257, 258]

In summary, our work reveals that the impact, which cellular reprogramming towards aerobic glycolysis exerts on cytoskeletal remodelling, probably goes beyond providing a fast local ATP supply

Overall, as there is heterogeneity in study designs, treatments and dosages, there is a need for further research on this topic which can enable us to conclude

IGF-1R Antibodies Monoclonal antibodies that target IGF-1R have shown benefit in early-stage clinical trials (Wang et al., 2005

In this study we report on an oxaliplatin-based platinum(IV) prodrug, which releases L -buthionine- S , R -sulfoximine (BSO), an inhibitor of glutamate-cysteine ligase, the rate-limiting enzyme in GSH biosynthesis