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Utilizing transcriptomics, we recently reported that the loss of AGXT suppresses FAO pathways and accelerates diet-induced MASH in mice 12

Specifically, most metazoans use the transsulfuration pathway to move the reduced S from Hcy to Cys, thereby using the Met cycle to feed the production of Cys and Cys-derived products, including GSH, taurine, and CoA

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