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Patients on GLP-1 medications such as semaglutide or tirzepatide are often prescribed Tesamorelin or CJC/Ipamorelin alongside to preserve muscle mass and improve body composition as they lose weight

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et al., Selective and membrane-permeable small-molecule inhibitors of nicotinamide N-methyltransferase reverse high-fat diet-induced obesity in mice, Biochem Pharmacol, 2018