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Furthermore, T cells pretreated with 1,25(OH) 2 D 3 exerted enhanced antitumor activity in vitro and in vivo upon transfer into immunodeficient mice transplanted with human tumor cells

In the same year, Hopkins was awarded the Nobel Prize for this and other work on vitamins and related nutritional factors

The benefits of blocking pro-inflammatory signaling further emphasize its potential role in the initiation and aggravation of CIPN

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Moreover, ROS-related hypoxia genes also exhibited differing expression patterns in this dataset (Supplementary Fig