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Since defects in DNA mismatch repair genes generate frame-shift mutations giving rise to highly immunogenic neoepitopes, we postulated that vaccination with these mutant peptide antigens could offer promising treatment options to LS patients

Research has shown that brain neurons stimulated by acetylcholine are receptive to stimulation by ALC

refrigerate after reconstitution Melanotan II binds to melanocortin receptors (primarily MC1R and MC4R), which are involved in melanin synthesis and mood regulation

Clin Cancer Res 13(11):3380-3387, 2007

Astrocytes display cell autonomous and diverse early reactive states in familial amyotrophic lateral sclerosis