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determined that ferroptosis is a key mechanism underlying blood-retinal barrier damage in diabetic retinopathy, demonstrating that Flotillin-1 activates the Nrf2 pathway by enhancing its expression and promoting its nuclear translocation, thereby stimulating the SLC7A11/GPX4 pathway to inhibit lipid peroxidation and ferroptosis [168]
Cell 167 , 16231635 (2016)
Newman A C , Maddocks O D K
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Bock, K
