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Description
Continuous, daily usage without breaks is generally not recommended due to the lack of extensive human data and potential risks 1 2

Methylation is then carried out by DNA methyltransferase and histone methyltransferase enzymes

J Appl Physiol (2011) Ruff D, et al

Warnings: Consult your health care professional prior to use if you are pregnant, trying to become pregnant, breastfeeding, taking medication, have a medical condition, or anticipate surgery

For oral dosing, yes taking it with food reduces absorption
