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Chronic low-grade inflammation often accompanies obesity and can persist even as weight decreases

Environmental toxicants such as bisphenol A (BPA) and nickel also induce ROS-mediated ER stress, further disrupting reproductive homeostasis [132,133,134]

Our findings delineate a novel mechanism of communication from mitochondria to the ER, reveal an unexpected protective role for GSSG, and provide a plausible pathway by which ER homeostasis is linked to metabolic activity

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