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Removal or destruction of the stomach: Vitamin B 12 deficiency can develop in people who have had surgery to remove part or all of the stomach

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Allergic reactions to b12 formulations True allergy to b12 itself remains extremely rare

This early mechanistic work provided the rationale for moving AOD9604 into human clinical trials

We assumed that a physician visit to explain to patients the benefits of oral therapy and instructions for use would take place on the day they came in to receive their intramuscular injection, and so this visit was not added to the conversion cost