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IUPHAR review - glucagon-like peptide-1 (GLP-1) and substance use disorders: an emerging pharmacotherapeutic target
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To further investigate how the three missense mutations (I20B Q, L23B R and V24B N, Figure 2) led to a significantly increased GLP-1R ECD binding affinity, a comprehensive structural biophysical analysis [34] was conducted for the 10000 structural models of semaglutide mutant 524 built by Modeller [29]
