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There are still obstacles to solving the membrane permeability of SODs and the persistence of enzyme action, which is still a hot spot and difficulty in mining the effect of SODs and promoting their application in the future

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Notably, the three-dimensional structure indicates that OsDHAR contains a broad, uncharged cleft between the 2-helix and the 3-helix as the putative binding site for non-native protein folding intermediates for its chaperone-like activity

Furthermore, reversible oxidative post-translational modifications of protein cysteines, particularly GS-ylation, were dramatically increased in the aortas of a Marfan syndrome mouse model

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