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In renal impairment, this axis contributes to a feedback loop driven by gut dysbiosis, systemic inflammation, oxidative stress, blood pressure dysregulations, and neurocognitive decline (Bugnicourt et al., 2013

J Clin Periodontol 21:4547 Nizam N, Discioglu F, Saygun I, et al

Importantly, research has indicated that BHMT also plays a significant role in methionine recycling in extrahepatic tissues, such as in breast cancer
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However, these drugs do not cure dementiathey only help manage symptoms and may become less effective as the disease progresses
