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Collectively, these findings suggest that the integration of non-pharmacological strategies, such as HBOT, with pharmacological treatments may serve to optimize the therapeutic outcomes while potentially minimizing the dosage of medication required

On the contrary, this NRF2 signature did not have the same immunoevasive phenotype in other non-squamous cancer types including renal papillary carcinoma, hepatocellular carcinoma or bladder carcinoma [63]

(2020) 53:e12891

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30 The diverse protective and regenerative capacity of NAD+ has been attributed to its involvement in the prevention of multiple hallmarks of cellular aging (Table 1)