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[DOI] [PubMed] [Google Scholar] 13.Hou D., Li F

Tumor microenvironmental signals triggered ATF4-mediated activation of PHGDH, leading to a redox-dependent mechanism that regulated tumor overgrowth

a maintenance dose of 50 mg/kg (to a maximum of 3 g/dose) administered every 8 hours may be used

DiJoseph JF, Armellino DC, Boghaert ER, Khandke K, Dougher MM, Sridharan L, Kunz A, Hamann PR, Gorovits B, Udata C, Moran JK, Popplewell AG, Stephens S, Frost P, Damle NK (2004a) Antibody-targeted chemotherapy with CMC-544: a CD22-targeted immunoconjugate of calicheamicin for the treatment of B-lymphoid malignancies

The choice of CAR signaling domains and cell culture condition adjustments affect the frequency of central memory T (T CM ) cells, degree of mitochondrial biogenesis, and fatty acid oxidation (FAO) rate, which influence CAR-T cell proliferative capacity and survival and patient treatment efficacy [9,10,11]