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Concretely, GPX4 uses GSH as the substrate to reduce phospholipid hydroperoxides (PLOOHs) to hydroxyl derivatives (PLOHs), and oxidizes GSH to GSSH, therefore alleviating the damage of oxidative stress to tumor cells ( As a case in point, Li and co-workers loaded dihydroartemisinin (DHA) into iron-based MOFs to design a peroxidase-like nanoreactor (termed DHA@MIL-101 NR) for synergistic CDT-ferroptotic therapy (Figure 5C) ( 3+ , achieving GSH consumption-mediated redox reaction and Fe 2+ -mediated Fenton reaction (Figure 5D)

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These alterations enhance the compounds capacity to engage with bacterial targets (Huber 2023)

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ADMET and physicochemical assessments in drug design

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It takes the average healthy person around 15 to 45 minutes after drinking alcohol to feel its symptoms

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Of developmental importance, perturbation in the metabolome in cord blood and urine samples of neonates is associated with intrauterine growth restriction (IUGR) and early growth perturbations, respectively 8,9

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