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The researchers also identified a new DddAtox homolog from Ruminococcus sp
Mechanistically, in contrast with the canonical doctrine that GSH globally maintains proteins in a reduced state, we show that GSH depletion selectively oxidizes and promotes the degradation of fatty acid synthase (FASN), a key regulator of lipid metabolism
doi: 10.3390/nu15030551
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Ranson HR, Cornel AJ, Fournier D, Vaughan A, Collins FH, Hemingway J
