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Gossypol and an HMT G9a inhibitor act in synergy to induce cell death in pancreatic cancer cells

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activation of cytochrome c and the apoptotic machinery

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M.GloverE

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Some clinicians recommend adding a bile acid sequestrant (like cholestyramine) if GI side effects become severe, though this should only be done under medical guidance

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2.10 Clonogenic survival assay Cells were treated with the indicated drugs, then collected, counted, diluted, then finally seeded into 6-well plate at an appropriate density for each treatment

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