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Macroscopic arthritis (swelling and redness) developed between days 6 and 23 after injection of autoantibodies to native and citrullinated cartilage proteins, which was enhanced by lipopolysaccharide (LPS) on day 5 (Fig

It is also an important agent for the first step of the adaptive immunity, consisting of the antigen presentation by antigen presenting cells (Peterson et al

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Cancer 58 , 400406 (1994)

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