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Takashi Inamoto for pointed advice and discussion when writing this paper

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Its anxiolytic effect is comparable to low-dose benzodiazepines but without the sedation, tolerance, dependence, or cognitive impairment associated with that drug class

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Abstract Vascular dementia (VaD) is a neurodegenerative disorder characterized by chronic oxygen insufficiency, leading to the generation of oxygen-free radicals, inflammatory responses, disturbances in iron metabolism, lipid peroxidation, and other pathological changes that disrupt intracellular homeostasis