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In LPS-stimulated BV-2 microglial cells, ISA can activate the GSK-3 and its downstream Nrf2 and HO-1, which suppressed the activation of NF-B and the subsequent production of inflammatory mediators, causing the inhibition of inflammation (Wang et al., 2018a)

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Cardiac-targeted delivery of nuclear receptor ROR via ultrasound targeted microbubble destruction optimizes the benefits of regular dose of melatonin on sepsis-induced cardiomyopathy

They also have cancer prevention potential by clearing cancer risk factors (Table 4)

Resveratrol exerts neuroprotection in PD by reducing ROS, and preventing the apoptosis of dopaminergic neurons