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Biguanide-derived neuroprotective agent (metformin) To mitigate neuroinflammation and mitochondrial dysfunction in PD, metformin was encapsulated into PLGA, which were further coated with BV2 microglial cell membranes to enhance the targeting efficiency to neuroinflammatory sites (BV2-metformin-loaded PLGA) for intranasal administration 19

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120 Using a mouse ischemia model, a previous study has demonstrated that -catenin-mediated signaling was activated in cardiac macrophages, especially in pro-inflammatory subsets

[DOI] [PubMed] [Google Scholar] 96.Said S., Moubarz G., Awadalla H., et al

ALA needs to be converted to EPA and DHA in the body by enzymes, with only an estimated 10-15% of dietary ALA being converted to EPA and DHA