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The effect of transforming growth factor-beta on cell proliferation and collagen formation by lung fibroblasts

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doi: 10.1002/anie.201007871

The trajectory begins with normal epithelial cells (diploid, state 2) and then progresses in two separate directions, with one direction leading to a carcinogenesis-like state but ending with normal cells (state 1), while the other direction eventually ending with malignant cells (state 3)