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We hypothesized that surface modification of poly(lactic-co-glycolic acid) (PLGA) nanoparticles with rabies virus glycoprotein (RVG29) would increase residence time and exposure of encapsulated payload to the CNS compared to non-targeted nanoparticles

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The arrival of nociceptive information at the dorsal horn of the spinal cord prompts neurons to release vesicles containing substance P, acting as a neuromodulator, along with other substances such as calcitonin gene-related peptide (CGRP) [46,48]

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doi:10.33549/physiolres.930478