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Compounds such as EGCG and apigenin promote apoptosis in melanoma cells by modulating pathways like MAPK and PI3K-AKT, while green tea polyphenols inhibit histone deacetylase (HDAC) and activate histone acetyltransferase (HAT), reactivating tumor-suppressor genes silenced during melanoma progression 138,148

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Cardiovascular outcome benefits have been established primarily in people with type 2 diabetes for certain GLP-1 receptor agonists, with evidence in non-diabetic populations still emerging

BPC 157 and VEGF Illustrating such control of angiogenesis, this could also be performed with VEGF

doi: 10.1038/s41423-020-00630-3 14 QinXMaDTanYWangHCaiZ