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Hydroperoxides (ROOH) Hydroperoxides are unstable compounds formed via lipid (LOOH), protein (POOH), and DNA oxidation, originating primarily from three hepatic sources: (1) electron leakage from the mitochondrial electron transport chain (particularly Complex I/III), (2) ROS-generating activity of CYP2E1, and (3) the NOX enzyme family (predominantly NOX4)

Red blood cell metabolism in Rhesus macaques and humans: Comparative biology of blood storage

This is because alcohol is not absorbed into fatty tissue and is therefore concentrated in a smaller body mass

For instance, microRNA-375-3p has been shown to alleviate salicylate-induced neuronal injury in vitro by targeting ELAVL4 and subsequently modulating NR2B expression and ROS production, pointing to potential upstream targets for intervention (Zhu et al., 2024)