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Long-term exposure to UV radiation can induce inflammation and enhanced skin fibroblasts which can produce SCF that can bind to its receptor (c-KIT receptor or more specifically m-KIT receptor) and therefore melanin production through the activation of tyrosine kinase paths in melanocytes (Yuan and Jin, 2018

10.1590/1678-4324-2018180013 15 AlvaradoK.BolaosM.CamachoC.QuesadaE.Vega-BaudritJ

Therefore, ferrum deposition in different organs in the body is closely related to red blood cell infusion (Unal et al., 2014)

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