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BPC-157 demonstrates unique capabilities in modulating the nitric oxide system, exhibiting context-dependent regulation that supports healing while avoiding excessive inflammatory responses

Abbreviations 7-CK: 7-chlorokynurenate, glycine-site antagonist ABD: Agonist binding domain AMP: Adenosine monophosphate AMPAR: -amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor AP2: Endocytic adaptor protein 2 BAPTA: (1,2-bis(o-aminophenoxy)ethane-N,N,N,N-tetraacetic acid Ca 2+ : Calcium CAMKII: Calcium/calmodulin kinase II CGP-78608: Glycine-binding site antagonist CTD: C-terminal domain d-APV: Glutamate-binding site antagonist FLIM: Fluorescence lifetime imaging FRET: Fluorescence resonance energy transfer GluN1: Glycine-binding NMDA receptor subunit 1 GluN2: Glutamate-binding NMDA receptor subunit 2 GluN3: Glycine-binding NMDA receptor subunit 3 GTP: Guanosine triphosphate K + : Potassium LTD: Long-term depression LTP: Long-term potentiation MAPK: Mitogen-activated protein kinase MK-801: Ion pore blocker Na + : Sodium NMDAR: N-methyl-D-aspartate receptor NTD: Amino-terminal domain PI3K: Phosphatidylinositol 3 kinase PKA: Protein kinase A PSD: Post-synaptic density SFK: Src family kinase TMD: Transmembrane domain References Grand T, Abi Gerges S, David M, Diana MA, Paoletti P

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