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Gleiter CH, Schreeb KH, Freudenthaler S, et al

Sprong RC, Winkelhuyzen-Janssen AM, Aarsman CJ, van Oirschot JF, van der Bruggen T, van Asbeck BS

440 ATP7B encodes a transmembrane copper transport ATPase, and mutations in ATP7B cause Wilsons disease by impairing copper homeostasis, leading to copper overload in the liver, brain, and other organs

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Down-regulation of VGF impairs biogenesis of glucagon granules and suppresses glucagon hypersecretion To further elucidate the role of VGF in glucagon hypersecretion, we employed adenovirus-mediated shRNA targeting Vgf (Supplementary Fig