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Description
As part of their metabolic reprogramming, cancer cells preferentially reduce pyruvate to L-lactate, shifting from OXPHOS to glycolysis to meet their energy and biosynthetic demands, even under aerobic conditions [1] (Fig
To study hierarchical descent more informative GO terms, enriched FAT GO terms were analysed and the list of significant terms was reduced to semantically non-redundant list of representative FAT GO terms with REVIGO 157
Acknowledgements We thank D
Withaferin A (WA) has been found to not only inhibit the activity of GPX4 in neuroblastoma but also activate heme oxygenase-1 to increase intracellular Fe 3+ concentration, thereby inducing ferroptosis in neuroblastoma [136]
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