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doi: 10.2147/JIR.S307081

The chromosomes, genes, and locations of these bb-CpGs in respect to gene structure and CpG islands are shown in Supplementary Table 2

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However, seized counterfeit tablets frequently display manufacturing defects not present in pharmaceutical-grade production: Visual warning signs in a potentially counterfeit M365 pill: Color irregularities: off-white, yellowish, or speckled coloring compared to the uniform clinical white of authentic Mallinckrodt tablets Imprint defects: shallow, smudged, off-center, or unevenly spaced M365 characters that lack the clean, consistent depth of pharmaceutical stamping Surface texture anomalies: chalky, powdery, or crumbling consistency compared to the firm, smooth surface of authentic compressed tablets Dimensional inconsistency: variable pill sizes or weights within a single batch, indicating imprecise pressing equipment Score line irregularities: off-center placement, uneven depth, or absent center line on the tablet face The chocolate chip cookie effect applies to fentanyl distribution within counterfeit batches: fentanyl concentrates unevenly across pressed pills, so one tablet may contain a lethal dose while an adjacent pill from the same batch contains none