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also found that in cisplatin-resistant ovarian cancer cells, KDM3A can activate SOX2 and inhibit p53 activity through demethylating p53, thereby downregulating the expression of apoptosis-related protein BCL-2 and p21, while inhibiting KDM3A can block the drug-resistant cells in G2/M phase (Fig

Loss-of-function mutations in YY1AP1 lead to grange syndrome and a fibromuscular dysplasia-like vascular disease

The selection of the ligand may be done according to the specific binding site of a target, but this manner of selection may fail owing to the fact that immobilization process may change binding affinity

596 CircPDIA3 can inhibit proptosis, thereby promoting oxaliplatin resistance in CRC 597 (Fig